반응 #618362

반응 방정식

Hydrazine monohydrate

2,4-dichloro-7-methylthieno[3,2-d]pyrimidine

→

2-chloro-4-hydrazino-7-methylthieno[3,2-d]pyrimidine

수율 90.0%

용매

EtOH

반응 조건

후처리

1. 1
   여과The solid was filtered
2. 2
   세척washed with H2O
3. 3
   기타dried

실험 절차

Hydrazine monohydrate (2.21 mL; 45.6 mmol; 2.0 equiv) was added to a suspension of 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine (5 g; 22.8 mmol; 1.0 equiv) in 40 mL of EtOH. The reaction was stirred at ambient temperature for 2 days. The solid was filtered, washed with H2O and dried to give 2-chloro-4-hydrazino-7-methylthieno[3,2-d]pyrimidine as an off-white solid (4.4 g; 90% yield); MS (ES) 214.97 (M+H), 212.99 (M−H).

출처