반응 #61836

반응 방정식

2-bromo-1-(napth-1-yl)-1-propanone

sodium acetate

→

title compound

2-acetoxy-1-(naphth-1-yl)-1-propanone

용매

ethanol

반응 조건

후처리

1. 1
   온도The mixture was cooled
2. 2
   기타evaporated in vacuo
3. 3
   기타The residue was partitioned between ethyl acetate and water
4. 4
   기타The organic layer was separated
5. 5
   세척washed with water, brine
6. 6
   건조dried with sodium sulphate
7. 7
   여과filtered
8. 8
   기타evaporated in vacuo

실험 절차

2-bromo-1-(napth-1-yl)-1-propanone (2 g) and sodium acetate (0.63 g) were boiled under reflux in anhydrous ethanol (10 ml) for 16 hours. The mixture was cooled and evaporated in vacuo. The residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with water, brine, dried with sodium sulphate, filtered and evaporated in vacuo. The title compound was obtained as an oil (0.75 g) following silica gel column chromatography of the residue in 50% dichloromethane in petroleum ether.

출처