반응 #61751

반응 방정식

bromoethyl pyruvate

3-(2-nitro-3-piperidin-1-yl-phenyl)-2-oxo-propionic acid ethyl ester

potassium ethoxide

→

3-(2-nitro-3-piperidin-1-yl-phenyl)-2,5-dioxo-hexanedioic acid di ethyl ester

용매

water

ether

THF

반응 조건

후처리

1. 1
   기타partitioned
2. 2
   세척the aqueous layer is washed with ether
3. 3
   건조The combined organic layers are dried over MgSO4
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

A solution of 3-(2-nitro-3-piperidin-1-yl-phenyl)-2-oxo-propionic acid ethyl ester (ii) in THF is treated with potassium ethoxide (“KOEt”) (1 eq), followed by bromoethyl pyruvate (1.05 eq), at 0° C. The reaction is allowed to warm to room temperature over 90 min. The reaction is diluted with water and ether, partitioned, and the aqueous layer is washed with ether. The combined organic layers are dried over MgSO4, filtered and concentrated. Chromatography gives 3-(2-nitro-3-piperidin-1-yl-phenyl)-2,5-dioxo-hexanedioic acid di ethyl ester (iii).

출처