반응 #61660

반응 방정식

5-acetyl-7-benzyloxy-1H-quinolin-2-one

benzyltrimethylammonium dichloriodate

sodium carbonate

sodium sulphite

dichloroethane

→

7-benzyloxy-5-(2-chloro-acetyl)-1H-quinolin-2-one

용매

water

acetic acid

반응 조건

후처리

1. 1
   기타at 65° C
2. 2
   세척washed with water
3. 3
   기타dried

실험 절차

7.0 g (23.9 mmol) 5-acetyl-7-benzyloxy-1H-quinolin-2-one and 19.0 g (54.6 mmol) benzyltrimethylammonium dichloriodate are stirred in 43 mL acetic acid, 7 mL water and 147 mL dichloroethane at 65° C. After 4.5 hours the raction is stopped by the addition of 400 mL sodium carbonate solution and 50 mL 5% sodium sulphite solution. The insoluble constituents are suction filtered, washed with water and dried.

출처