반응 #61659

반응 방정식

5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one

2,3-dichloro-5,6-dicyanobenzoquinone

→

5-acetyl-7-benzyloxy-1H-quinolin-2-one

용매

dioxane

반응 조건

후처리

1. 1
   온도The mixture is refluxed for 30 minutes
2. 2
   여과The solid is filtered off
3. 3
   세척washed with dioxane
4. 4
   workup.DISSOLUTIONdissolved in 600 mL dichloromethane/methanol (9:1)
5. 5
   세척The solution is washed with sodium hydrogen carbonate solution
6. 6
   건조dried with sodium sulphate
7. 7
   기타evaporated down
8. 8
   여과filtered
9. 9
   기타dried

실험 절차

13.0 g (44 mmol) 5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one are suspended in 130 mL dioxane and combined with 15.0 g (66 mmol) of 2,3-dichloro-5,6-dicyanobenzoquinone. The mixture is refluxed for 30 minutes, cooled to ambient temperature and stirred for a further 2 hours. The solid is filtered off, washed with dioxane and dissolved in 600 mL dichloromethane/methanol (9:1). The solution is washed with sodium hydrogen carbonate solution, dried with sodium sulphate and evaporated down. Then the residue is suspended in methanol, filtered and dried.

출처