반응 #61654

반응 방정식

7-acetyl-5-benzyloxy-3H-benzoxazol-2-one

selenium dioxide

charcoal

dioxane

→

5-benzyloxy-7-(2-ethoxy-2-hydroxy-acetyl)-3H-benzoxazol-2-one

용매

water

반응 조건

후처리

1. 1
   여과The solid is filtered off
2. 2
   workup.DISTILLATIONthe solvent is distilled off
3. 3
   온도The mixture is refluxed for 15 minutes
4. 4
   여과filtered through activated charcoal
5. 5
   기타The solid precipitated
6. 6
   온도on cooling
7. 7
   여과is suction filtered after 3 hours
8. 8
   세척washed with ethanol and diethyl ether

실험 절차

20 g (71 mmol) 7-acetyl-5-benzyloxy-3H-benzoxazol-2-one and 8 g (72 mmol) selenium dioxide are refluxed for 8 hours in the presence of activated charcoal in 100 mL dioxane and 3.1 mL water. The solid is filtered off, the solvent is distilled off and the residue is combined with 50 mL ethanol. The mixture is refluxed for 15 minutes and then filtered through activated charcoal. The solid precipitated on cooling is suction filtered after 3 hours and washed with ethanol and diethyl ether.

출처