반응 #615729

반응 방정식

1-methylpiperazine

4-bromo-3-fluorobenzotrifluoride

→

1-(2-bromo-5-(trifluoromethyl)phenyl)-4-methylpiperazine

반응 조건

후처리

1. 1
   농축The reaction was concentrated under a vacuum
2. 2
   여과the solids were then filtered
3. 3
   세척washed with DCM (solids
4. 4
   농축The filtrate was then concentrated under a vacuum

실험 절차

A microwave vial was charged with 1-methylpiperazine (1.371 mL, 12.35 mmol) and 4-bromo-3-fluorobenzotrifluoride (1.000 mL, 4.12 mmol), and was heated under microwave irradiation at 180° C. for 90 minutes. The reaction was concentrated under a vacuum, and the solids were then filtered and washed with DCM (solids contained only minor amounts of product). The filtrate was then concentrated under a vacuum to yield 1-(2-bromo-5-(trifluoromethyl)phenyl)-4-methylpiperazine, mixed with starting bromide. Material was used without further purification.

출처