반응 #6156

반응 방정식

(3S,4S,6R)-tetrahydro-3-hexyl-4-hydroxy-6-undecyl-2H-pyran-2-one

t-butyldimethylchlorosilane

ether

→

(3S,4S,6R)-tetrahydro-3-hexyl-4-[(t-butyldimethylsilyl)oxy]-6-undecyl-2H-pyran-2-one

수율 63.5%

용매

DMF

DMF

반응 조건

후처리

1. 1
   기타The reaction mixtures
2. 2
   세척washed with 1N hydrochloric acid
3. 3
   기타The organic phase was dried
4. 4
   여과filtered
5. 5
   기타evaporated
6. 6
   기타The material obtained
7. 7
   기타was chromatographed on silica gel

실험 절차

M)d) 1.5 g of (3S,4S,6R)-tetrahydro-3-hexyl-4-hydroxy-6-undecyl-2H-pyran-2-one were dissolved in 8 ml of DMF. 0.85 g of t-butyldimethylchlorosilane in 4 ml of DMF were then added dropwise. The mixture was stirred for 48 hours. The reaction mixtures was poured in to 100 ml of ether and washed with 1N hydrochloric acid. The organic phase was dried, filtered and evaporated. The material obtained was chromatographed on silica gel. There was obtained 1.26 g of (3S,4S,6R)-tetrahydro-3-hexyl-4-[(t-butyldimethylsilyl)oxy]-6-undecyl-2H-pyran-2-one, MS: 411 (M+ -t-butyl).

출처