반응 #61556

반응 방정식

Prop-2-yn-1-ol

Ethyl diazoacetate

→

5-Hydroxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester

용매

trichloromethane

반응 조건

후처리

1. 1
   기타Then the solvent was removed under reduced pressure
2. 2
   기타the residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2
3. 3
   workup.ADDITIONThe fractions containing the product
4. 4
   기타were collected
5. 5
   기타evaporated under reduced pressure

실험 절차

A solution of 2 g Prop-2-yn-1-ol and 3 g Ethyl diazoacetate in 16 ml trichloromethane was stirred at 70° C. for 24 h. Then the solvent was removed under reduced pressure and the residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2. The fractions containing the product were collected and evaporated under reduced pressure. Yield: 1.9 g.

출처