반응 #61508

반응 방정식

6-{5-[3-(5,5-Dimethyl-[1,3]dioxan-2-yl)-propylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-quinoline

sulphuric acid

sodium carbonate

→

title compound

수율 95.0%

4-(4-Methyl-5-quinolin-6-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-butyraldehyde

수율 95.0%

용매

water

반응 조건

후처리

1. 1
   온도The mixture was cooled
2. 2
   추출The aqueous mixture was extracted with dichloromethane (3×50 ml)
3. 3
   건조the combined organic portions were dried (Na2SO4)
4. 4
   여과filtered
5. 5
   기타evaporated

실험 절차

6-{5-[3-(5,5-Dimethyl-[1,3]dioxan-2-yl)-propylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-quinoline (0.51 g, 1.28 mmol) was heated in water (30 ml) and sulphuric acid (1.92 mmol) at 100° C. for 3 h. The mixture was cooled and basified with sodium carbonate. The aqueous mixture was extracted with dichloromethane (3×50 ml) and the combined organic portions were dried (Na2SO4), filtered and evaporated to give the title compound as a colourless oil (0.38 g, 95%).

출처