반응 #61504

반응 방정식

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide

→

title compound

수율 10.0%

6-[5-(3-[1,3] Dioxan-2-yl-propyl)-4-methyl-4H-[1,2,4] triazol-3-yl]-2-methyl-quinoline

수율 10.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   기타the residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which

실험 절차

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide (1.28 g, 3.4 mmol) was heated in ethyl acetate (20 ml) for 4 h. The solvent was evaporated and the residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which gave the title compound as a brown solid (109 mg, 10%).

출처