반응 #61443

반응 방정식

2-chloroquinoline

piperazine-1-carboxylic acid tert-butyl ester

potassium carbonate

→

title compound

4-Quinolin-2-yl-piperazine-1-carboxylic Acid Tert.-butyl Ester

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   농축The reaction mixture is concentrated
3. 3
   workup.ADDITIONwater is added
4. 4
   추출the compound extracted with ethyl acetate

실험 절차

A mixture of 6.1 mmol 2-chloroquinoline, 6.7 mmol piperazine-1-carboxylic acid tert-butyl ester and 12.2 mmol potassium carbonate in 15 ml acetonitrile was refluxed overnight. The reaction mixture is concentrated, water is added and the compound extracted with ethyl acetate. Chromatography (SiO2; cyclohexane/ethyl acetate 9/1) gave the title compound as a colorless solid.

출처