반응 #61198

반응 방정식

2-bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-4-carbonitrile

i-PrMgCl

ethyl cyanoformate

→

colorless oil

수율 75.2%

4-Cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid ethyl ester

수율 75.2%

용매

THF

THF

반응 조건

후처리

1. 1
   온도cooled to −78° C.
2. 2
   기타to attain RT
3. 3
   workup.STIRRINGstirred for 1 h
4. 4
   기타The reaction was quenched with satd aq NH4Cl
5. 5
   workup.ADDITIONdiluted with EtOAc (20 mL)
6. 6
   세척washed with brine (2×20 mL)
7. 7
   건조the organic layer was dried over Na2SO4
8. 8
   농축concentrated
9. 9
   세척The title compound was eluted from a 20-g SPE cartridge (silica) with 30% EtOAc/hexane

실험 절차

To a solution of 2-bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-4-carbonitrile (0.55 g, 1.8 mmol) (as prepared in the previous step) in THF (6 mL) at −40° C. was added dropwise a solution of 2M i-PrMgCl in THF (1 mL). The reaction was allowed to stir for 10 min at −40° C. and then cooled to −78° C., and ethyl cyanoformate (0.3 g, 3.0 mmol) was added. The reaction allowed to attain RT and stirred for 1 h. The reaction was quenched with satd aq NH4Cl, diluted with EtOAc (20 mL) and washed with brine (2×20 mL), and the organic layer was dried over Na2SO4 and then concentrated. The title compound was eluted from a 20-g SPE cartridge (silica) with 30% EtOAc/hexane to give 0.40 g (74%) of a colorless oil. Mass spectrum (ESI, m/z): Calcd. for C13H21N3O3Si, 296.1 (M+H), found 296.1.

출처