반응 #611589

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2-{2-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-5-fluoro-thiazol-4-yl}-2-methyl-propionic acid ethyl ester

TFA

→

2-(2-Amino-5-fluoro-thiazol-4-yl)-2-methyl-propionic acid ethyl ester

수율 97.8%

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실험 절차

The reaction was done by the same way as mentioned in the preparation 45, step-V using 2-{2-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-5-fluoro-thiazol-4-yl}-2-methyl-propionic acid ethyl ester (0.5 g, 1.1 mmol) and TFA (5 mL) to afford 2-(2-Amino-5-fluoro-thiazol-4-yl)-2-methyl-propionic acid ethyl ester (0.25 g).

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