반응 #6111

반응 방정식

4-(4-iodophenyl)benzonitrile

sodium thiomethylate

→

pale yellow solid

수율 106.6%

4-(4-mercaptophenyl)benzonitrile

수율 106.6%

용매

hexamethylphosphoramide

반응 조건

후처리

1. 1
   추출The expected product is extracted with ethyl acetate
2. 2
   세척The resulting organic phase is washed with water until the pH of the washings
3. 3
   건조dried over magnesium sulfate
4. 4
   기타evaporated under reduced pressure

실험 절차

3.25 g (10.8.10-3 mol) of 4-(4-iodophenyl)benzonitrile are dissolved in 50 ml of hexamethylphosphoramide, and 3.05 g (43.4.10-3 mol) of sodium thiomethylate are then added to the solution. The reaction mixture is heated at 100° C. for 1.5 hours and then, after cooling, hydrolyzed in a 1 N hydrochloric acid/ice mixture. The expected product is extracted with ethyl acetate. The resulting organic phase is washed with water until the pH of the washings is neutral, dried over magnesium sulfate and then evaporated under reduced pressure to give 2.4 g (quantitative yield) of a pale yellow solid.

출처