반응 #61078

반응 방정식

6-bromo-2-pyridinamine

1-chloro-2-isocyanatoethane

→

title compound

수율 66.0%

N-(6-Bromo-2-pyridinyl)-N′-(2-chloroethyl)urea

수율 66.0%

용매

THF

반응 조건

후처리

1. 1
   기타The crude mixture was partitioned between CH2Cl2 and water
2. 2
   기타The phases were separated
3. 3
   건조the organic layer was dried over anh. Na2SO4
4. 4
   여과The solids were filtered
5. 5
   기타the solvent evaporated

실험 절차

To a solution of 6-bromo-2-pyridinamine (1 g, 5.78 mmol) in anh. THF (25 mL), at r.t., under N2, was added 1-chloro-2-isocyanatoethane (1.2 mL, 2.5 eq) and the reaction mixture was stirred at r.t. for 18 hr. The crude mixture was partitioned between CH2Cl2 and water. The phases were separated and the organic layer was dried over anh. Na2SO4. The solids were filtered and the solvent evaporated to give the title compound (1.06 g, 66%) which was used in the next step without further purification.

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