반응 #61071

반응 방정식

3-aminopyrazole

NaHCO3

Ac2O

→

solid

N-1H-Pyrazol-3-ylacetamide

용매

H2O

반응 조건

후처리

1. 1
   기타at 5-10° C.
2. 2
   온도The reaction mixture was refluxed for 8 hr
3. 3
   workup.WAITwas left
4. 4
   기타crystallization
5. 5
   여과The white solid was filtered (12.9 g)

실험 절차

To a solution of 3-aminopyrazole (20 g, 0.24 mol) in H2O (36 mL), at 5-10° C., was slowly added NaHCO3 (9.1 g, mol, 3 eq) and then Ac2O (6.79 ml, 2 eq). The reaction mixture was refluxed for 8 hr. It was cooled down to r.t. and was left standing at this temperature for 12 hr to allow crystallization. The white solid was filtered (12.9 g) and the mother liquor volume was reduced. A second batch of white solid (3.4 g) was obtained after crystallization. The two batches were combined to give the title compound (16.3 g, 54%).

출처