반응 #610620

반응 방정식

methyl 3-thiophenecarboxylate

1-tetradecanol

methanesulfonic acid

→

desired compound

수율 92.4%

Tetradecylthiophene-3-carboxylate

수율 92.4%

용매

toluene

반응 조건

후처리

1. 1
   온도This mixture was heated
2. 2
   온도to reflux for 17 hours
3. 3
   기타After the solvent was removed
4. 4
   기타the remaining methyl 3-thiophenecarboxylate was removed by kugelrohr distillation
5. 5
   여과The remaining residue was filtered through a silica gel pad with 10% ethyl acetate in hexane
6. 6
   기타The solvents were removed from the filtrate

실험 절차

To a 200 mL round bottom flask were added 10 g (70 mmol) of methyl 3-thiophenecarboxylate, 17 g (79 mmol) of 1-tetradecanol, 1 mL methanesulfonic acid, and 50 mL of toluene. This mixture was heated to reflux for 17 hours. After the solvent was removed, the remaining methyl 3-thiophenecarboxylate was removed by kugelrohr distillation. The remaining residue was filtered through a silica gel pad with 10% ethyl acetate in hexane. The solvents were removed from the filtrate to provide 21 g of the desired compound. The NMR data were obtained and were consistent with those of the desired compound.

출처