반응 #61031

반응 방정식

N-Boc-Piperazine

2,3,4-trifluorobenzonitrile

→

title compound

수율 75.4%

4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

수율 75.4%

용매

DMA

DMA

반응 조건

후처리

1. 1
   기타After such time the solvent was removed in vacuo
2. 2
   기타purified by column chromatography (SiO2)

실험 절차

To a solution of N-Boc-Piperazine (0.65 g) in DMA (20 mL) was slowly added a solution of 2,3,4-trifluorobenzonitrile (0.49 g) in DMA (10 mL). The reaction mixture was stirred for 2 hours at 80° C. After such time the solvent was removed in vacuo and purified by column chromatography (SiO2) to yield the title compound as white solid (0.76 g).

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