반응 #610280

반응 방정식

6-bromo-2-methoxypyridin-3-amine

1,2-dimethyl-1H-imidazole

KOAc

→

title compound

수율 16.5%

6-(1,2-Dimethyl-1H-imidazol-5-yl)-2-methoxypyridin-3-amine

수율 16.5%

용매

DMA

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   workup.ADDITIONdiluted with NaCl solution
3. 3
   추출extracted with EtOAc
4. 4
   기타The organic layer was purified
5. 5
   세척by eluting through an SCX-2 column
6. 6
   세척eluting with 0-4% MeOH/EtOAc

실험 절차

A suspension of 6-bromo-2-methoxypyridin-3-amine (96 mg, 0.473 mmol), 1,2-dimethyl-1H-imidazole (91 mg, 0.946 mmol), Pd(OAc)2 (4.3 mg, 0.019 mmol), KOAc (93 mg, 0.95 mmol) in DMA (3 mL) was stirred at 1500 under microwave irradiation for 8 hours. The reaction mixture was filtered, diluted with NaCl solution and extracted with EtOAc. The organic layer was purified by eluting through an SCX-2 column using 2M NH3/MeOH followed by Biotage silica gel column chromatography eluting with 0-4% MeOH/EtOAc to give the title compound as pink solid (17 mg, 16%).

출처