반응 #608849

반응 방정식

2-amino-4-trifluromethylbenzamide

4-chloro-2-ethylsulfanylbenzaldehyde

sodium bisulfite

sodium bicarbonate

→

2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one

수율 80.7%

용매

DMA

water

반응 조건

후처리

1. 1
   여과the precipitated solid was filtered
2. 2
   세척The resulting solid was washed with water and n-hexane
3. 3
   기타dried

실험 절차

A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 944 mg of 4-chloro-2-ethylsulfanylbenzaldehyde, 765 mg of sodium bisulfite and 4 ml of DMA was stirred at 150° C. for 15 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.46 g of 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one.

출처