반응 #60884

반응 방정식

4-Methylthio-6-iodo-thieno[2,3-d]pyrimidine

Intermediate 91

4-Methylthio-6-iodo-thieno[2,3-d]pyrimidine

5-tributylstannyl-4-iodo-1-methyl-1H-imidazole

Intermediate 92

5-tributylstannyl-4-iodo-1-methyl-1H-imidazole

→

title compound

수율 67.3%

6-(4-Iodo-1-methyl-1H-imidazol-5-yl)-4-methylthio-thieno[2,3-d]pyrimidine

수율 67.3%

용매

DMF

반응 조건

후처리

1. 1
   기타degassed with nitrogen for 10 min
2. 2
   농축The reaction mixture was concentrated in vacuo
3. 3
   기타the crude product triturated with DCM (20 mL)

실험 절차

4-Methylthio-6-iodo-thieno[2,3-d]pyrimidine (Intermediate 91) (949 mg), 5-tributylstannyl-4-iodo-1-methyl-1H-imidazole (Intermediate 92) (2.76 g) and tetrakis(triphenylphosphine)palladium(0) (178 mg) were stirred in anhydrous DMF (50 mL), degassed with nitrogen for 10 min, then heated to 100° C. for 18 hours under an inert atmosphere. The reaction mixture was concentrated in vacuo and the crude product triturated with DCM (20 mL) to afford the title compound as a yellow solid (805 mg, 67%);

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