반응 #60880

반응 방정식

NaHCO3

6-Chloropyrimidine-4,5-diamine

Intermediate 88

6-Chloropyrimidine-4,5-diamine

HI

→

title compound

수율 98.0%

6-Iodopyrimidine-4,5-diamine

수율 98.0%

반응 조건

후처리

1. 1
   workup.WAITat ambient temperature for 24 hours
2. 2
   추출The product was extracted with EtOAc (3×15 mL)
3. 3
   건조The combined organics were dried (MgSO4)
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

6-Chloropyrimidine-4,5-diamine (Intermediate 88) (90 mg) was added slowly to HI (57%, aq) (2 mL) at 0° C. The reaction mixture was allowed to stir at 0° C. for 30 minutes and then at ambient temperature for 24 hours. NaHCO3 (sat aq.) was added dropwise until the reaction mixture was pH 8. The product was extracted with EtOAc (3×15 mL). The combined organics were dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a grey solid (144 mg, 98%);

출처