반응 #60870

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3-aminopyrrolidine

1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole

7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde

Intermediate 77

7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde

Intermediate 73

4-aminothieno[2,3-d]pyrimidine-6-carbaldehyde

→

title compound

2-[1-(Cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine

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후처리

1. 1
   기타was used in subsequent steps without further purification)

실험 절차

The title compound was prepared by a similar process to that described for Example 65 but using 7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde (Intermediate 77) in place of 4-aminothieno[2,3-d]pyrimidine-6-carbaldehyde (Intermediate 73) and using cyclohexamethylamine in place of 3-aminopyrrolidine. Yellow solid (542 mg) (the product contained 33% of 1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole but was used in subsequent steps without further purification);

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