반응 #608326

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3-amino-4-fluoro-benzoic acid

cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine

2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate

→

title compound

수율 68.0%

(3-Amino-4-fluoro-phenyl)-(cis-2,3,4,4a,9,9a-hexahydro-indeno[2,1-b]pyridin-1-yl)-methanone

수율 68.0%

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실험 절차

The title compound is prepared from 3-amino-4-fluoro-benzoic acid and cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1 [2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate is used]. Yield: 68% of theory; LC (method 4): tR=1.91 min; Mass spectrum (ESI+): m/z=311 [m+H]+.

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