반응 #60812
ord-69b889d0d7d7475b9bcc72634c317de5
반응 방정식
6-methyl-4-chlorofuro[2,3-d]pyrimidine
sodium thiomethoxide
→
title compound
수율 90.0%
6-Methyl-4-(methylthio)furo[2,3-d]pyrimidine
수율 90.0%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The mixture was filtered
- 2세척the solids washed with acetonitrile
- 3기타Evaporation of the solvent
실험 절차
A solution of 6-methyl-4-chlorofuro[2,3-d]pyrimidine (U.S. Pat. No. 3,577,420, example IG) (219 mg) in acetonitrile (25 mL) was heated under reflux with sodium thiomethoxide (190 mg) for 16 hours. The mixture was filtered and the solids washed with acetonitrile. Evaporation of the solvent afforded the title compound as a white solid (230 mg, 90%);