반응 #60790

반응 방정식

phosphoric acid

Phosphorous pentoxide

N-(4,6diaminopyrimidin-5-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide

intermediate 7

N-(4,6diaminopyrimidin-5-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide

NH3

→

title compound

수율 96.9%

8-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine

수율 96.9%

반응 조건

후처리

1. 1
   workup.ADDITIONIce was added to the cooled mixture, which
2. 2
   여과the resultant precipitate filtered off
3. 3
   세척washed with water
4. 4
   기타dried at 60° C. in vacuo

실험 절차

Phosphorous pentoxide (1.06 g) was added to N-(4,6diaminopyrimidin-5-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide (intermediate 7) (171 mg) followed by phosphoric acid (85%, 0.76 mL) and heated at 160° C. for 72 hours. Ice was added to the cooled mixture, which was then adjusted to pH 5 with aqueous NH3, the resultant precipitate filtered off, washed with water and dried at 60° C. in vacuo to give the title compound as a cream solid (156 mg, 89%);

출처