반응 #607448

반응 방정식

hex-5-enal

trimethyl(trifluoromethyl)silane

→

1,1,1-trifluorohept-6-en-2-ol

수율 31.0%

용매

THF

반응 조건

후처리

1. 1
   기타The ice bath was removed
2. 2
   workup.ADDITIONUpon complete transformation of the starting material the reaction mixture was treated with 2M HCl
3. 3
   workup.ADDITIONThen, 50 mL of Et2O was introduced
4. 4
   기타the layers were separated
5. 5
   추출The aqueous fraction was additionally extracted with Et2O
6. 6
   세척the combined organic phases were washed sequentially with a saturated aqueous NaHCO3 solution, water, and brine
7. 7
   건조After drying with MgSO4 and filtration the solvent
8. 8
   기타was removed under reduced pressure
9. 9
   기타the resultant crude residue was purified by column chromatography (silica gel, pentane/Et2O, v/v=8/2)
10. 10
    workup.ADDITIONFractions containing the pure compound
11. 11
    기타were collected
12. 12
    농축concentrated in vacuo

실험 절차

To a ice-bath cooled solution of hex-5-enal (500 mg, 4.331 mmol) and trimethyl(trifluoromethyl)silane (0.74 g, 5.13 mmol, 1.2 equiv.) in THF (10 mL) was added tetrabutylammonium hydrofluoride (10 mg, 0.04 mmol). The ice bath was removed and the reaction progress was monitored via GCMS and 1H NMR. Upon complete transformation of the starting material the reaction mixture was treated with 2M HCl and stirred for an additional 2 h. Then, 50 mL of Et2O was introduced and the layers were separated. The aqueous fraction was additionally extracted with Et2O and the combined organic phases were washed sequentially with a saturated aqueous NaHCO3 solution, water, and brine. After drying with MgSO4 and filtration the solvent was removed under reduced pressure and the resultant crude residue was purified by column chromatography (silica gel, pentane/Et2O, v/v=8/2). Fractions containing the pure compound were collected and concentrated in vacuo to give 1,1,1-trifluorohept-6-en-2-ol (225 mg, 31% yield) as a yellow oil.

출처