반응 #60736

반응 방정식

4-oxo-4-phenylbutyric acid

hydroxylamine hydrochloride

sodium acetate

water

→

4-Hydroximino-4-phenylbutyric acid

용매

EtOH

반응 조건

후처리

1. 1
   온도was then cooled to room temperature
2. 2
   기타afforded
3. 3
   기타after recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound

실험 절차

To a solution of 4-oxo-4-phenylbutyric acid (1.0 g, 5.3 mmol) in 50 mL of EtOH was added hydroxylamine hydrochloride (742 mg, 11 mmol) and sodium acetate (1.8 g, 21 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded, after recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound.

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