반응 #60709

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6-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]benzo[b]thiophene-2-carboxamide

acetone

→

6-Chloro-N-[1-(2-chlorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]benzo[b]thiophene-2-carboxamide

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후처리

1. 1
   기타afforded
2. 2
   기타after purification (SiO2: 4:4:1 hexane EtOAc:isopropylamine), 150 mg (54%) of the title compound

실험 절차

Using alkylation method A, 6-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]benzo[b]thiophene-2-carboxamide (255 mg, 0.55 mmol) and acetone (2.0 mL, 27 mmol) afforded, after purification (SiO2: 4:4:1 hexane EtOAc:isopropylamine), 150 mg (54%) of the title compound.

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