반응 #60706

반응 방정식

water

3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

potassium carbonate

2,2,2-trifluoroethyl trifluoromethane-sulfonate

→

title compound

수율 30.0%

3-Chloro-N-[1-(2-chlorophenyl)-2-[1-(2,2,2-trifluoroethyl)-piperidin-4-ylmethoxy]ethyl]-1H-indole-6-carboxamide

수율 30.0%

용매

DMSO

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타the resulting precipitate was isolated by filtration
3. 3
   기타Purification of the filtrate (SiO2: 30% EtOAc in hexane)

실험 절차

To a solution of 3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (700 mg, 1.6 mmol) in 5 mL of DMSO was added potassium carbonate (1.0 g, 7.9 mmol) and 2,2,2-trifluoroethyl trifluoromethane-sulfonate (364 mg, 1.6 mmol). The reaction was allowed to stir at room temperature overnight after which time water was added and the resulting precipitate was isolated by filtration. Purification of the filtrate (SiO2: 30% EtOAc in hexane) provided 250 mg (30%) of the title compound.

출처