반응 #60662

반응 방정식

Cs2CO3

2,5-dichloropyridine

4-methylsulfonylphenol

Cs2CO3

→

5-chloro-2-{[4-(methylsulfonyl)phenyl]oxy}pyridine

용매

NMP

반응 조건

후처리

1. 1
   여과was filtered off
2. 2
   추출the solvent was extracted between H2O and EtOAc
3. 3
   건조The organic phase was dried over Na2SO4
4. 4
   기타evaporated
5. 5
   workup.ADDITIONHeptane:EtOAc 2:1 was added to the residue
6. 6
   여과the crystalls was filtered off 1.42 g (50%)

실험 절차

2,5-dichloropyridine (1.48 g; 10 mmol), 4-methylsulfonylphenol (1.89 g; 11 mmol) and Cs2CO3 (4.24 g; 13 mmol) was slurried in 75 mL of NMP. The slurry was heated to approx 170° C. over night. After cooling the Cs2CO3 was filtered off and the solvent was extracted between H2O and EtOAc. The organic phase was dried over Na2SO4 and evaporated. Heptane:EtOAc 2:1 was added to the residue and the crystalls was filtered off 1.42 g (50%).

출처