반응 #60660

반응 방정식

5-(3-Aminopropyl)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]imidazolidine-2,4-dione trifluoroacetic acid

DIPEA

Sulfonylchloride

→

N-{3-{4-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl}methyl]-2,5-dioxoimidazolidin-4-yl}propyl)methanesulfonamide

용매

DCM

반응 조건

후처리

1. 1
   workup.STIRRINGthe reaction was stirred at rt over night
2. 2
   기타The crude product was purified by preparative HPLC

실험 절차

5-(3-Aminopropyl)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]imidazolidine-2,4-dione trifluoroacetic acid (100 mg, 0.18 mmol) was slurried in 2 mL DCM. DIPEA (62 μL, 0.36 mmol) was added and the slurry was stirred for some minutes. Sulfonylchloride (16 μL, 0.18 mmol) was added and the reaction was stirred at rt over night. The crude product was purified by preparative HPLC.

출처