반응 #60640

반응 방정식

1-(4-methyl-2-methylamino-thiazol-5-yl)-ethanone

NaH

MeI

→

1-(2-dimethylamino-4-methyl-thiazol-5-yl)-ethanone

용매

THF

EtOAc

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   온도Heating
3. 3
   온도After cooling
4. 4
   세척washed with brine
5. 5
   건조dried over MgSO4
6. 6
   기타The solvent was evaporated

실험 절차

A mixture of 1-(4-methyl-2-methylamino-thiazol-5-yl)-ethanone (0.40 g, 2.4 mmol) in THF (2 mL) was treated with NaH (0.113 g, 4.7 mmol). After heating at 40° C. for 0.5 h MeI (0.35 g, 2.4 mmol) was added. Heating was continued for a further 2 h. After cooling, the solution was diluted with EtOAc, washed with brine, and dried over MgSO4. The solvent was evaporated to afford 1-(2-dimethylamino-4-methyl-thiazol-5-yl)-ethanone as a yellow solid. 1H-NMR (CDCl3) δ: 2.36 (s, 3H, CH3), 2.51 (s, 3H, CH3), 3.10 (s, 6H, CH3).

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