반응 #60578

반응 방정식

ethyl 3-oxo-3-(4-pyridyl)propionate

N-methyl thiourea

1,8-diazabicyclo[5,4,0]-7-undecene

methanesulfonic acid

→

title compound

수율 72.1%

2-mercapto-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one

수율 72.1%

용매

water

반응 조건

후처리

1. 1
   세척The precipitate was washed with water
2. 2
   여과filtered
3. 3
   기타dried

실험 절차

A solution of ethyl 3-oxo-3-(4-pyridyl)propionate (29.0 g, 150 mmol), N-methyl thiourea (40.6 g, 450 mmol) and 1,8-diazabicyclo[5,4,0]-7-undecene (22.4 ml, 150 mmol) was refluxed for 4 hours and the solution of methanesulfonic acid (14.4 g, 150 mmol) in water (50 ml) was added after cooling by ice-water. The precipitate was washed with water, filtered and dried to give the title compound (23.7 g, 72%).

출처