반응 #60542

반응 방정식

4-(5-fluoro-2-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester

→

title compound

수율 99.5%

4-(5-Fluoro-2-methoxyphenyl)piperidine-1-carboxylic acid t-butyl ester

수율 99.5%

용매

methanol

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through Celite
2. 2
   농축the obtained filtrate was concentrated under reduced pressure

실험 절차

To a solution of 4-(5-fluoro-2-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester (2.0 g, 6.5 mmol) produced in Example (106a) in methanol (30 mL) was added 10% palladium on carbon (0.99 g, wet), the mixture was stirred for 17 hours at atmospheric pressure and room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the obtained filtrate was concentrated under reduced pressure to give 2.0 g of the title compound as a light yellow oil.

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