반응 #60414

반응 방정식

1-[2-(4,4-dimethylcyclohex-1-enyl)-5-methoxyphenyl]-4-pentylpiperazine hydrochloride

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title compound

수율 38.4%

1-[2-(4,4-Dimethylcyclohexyl)-5-methoxyphenyl]-4-pentylpiperazine hydrochloride

수율 38.4%

용매

methanol

반응 조건

후처리

1. 1
   농축the filtrate was concentrated under reduced pressure
2. 2
   workup.ADDITIONDiethyl ether was added to the residue
3. 3
   여과the mixture was filtered

실험 절차

To a solution of 1-[2-(4,4-dimethylcyclohex-1-enyl)-5-methoxyphenyl]-4-pentylpiperazine hydrochloride (44 mg) prepared in Example (1f) in methanol (5 mL) was added 10% palladium on carbon (100 mg, wet), and the mixture was stirred for 17 hours under a hydrogen atmosphere at atmospheric pressure and room temperature. The reaction mixture was passed through Celite, and the filtrate was concentrated under reduced pressure. Diethyl ether was added to the residue and the mixture was filtered to give 17 mg of the title compound as a light yellow solid.

출처