반응 #6041
ord-7032a768e4ff40098e40773662a0af2f
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도is refluxed under nitrogen for 9 hours
- 2온도After cooling the mixture
- 3추출extracted with AcOEt
- 4기타evaporated to dryness
실험 절차
A mixture of 1-(4-fluorophenyl)hydrazine hydrochloride (1.03 g), ethyl 4-oxo-hexanoate (1.0 g), 2-propanol (25 ml) and H2SO4 is refluxed under nitrogen for 9 hours. After cooling the mixture is poured into a aqueous solution of NaHCO3, extracted with AcOEt and evaporated to dryness to yield 1.45 g of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate.