반응 #60389

반응 방정식

3-(3,4-dichloro-benzenesulfonylamino)-3-phenyl-propionic acid

6-(2-dimethylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-1-ylamine

EDC

HOBt

→

title compound

3-(3,4-dichloro-benzenesulfonylamino)-N-[6-(2-dimethylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-3-phenyl-propionamide

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   기타To a 20 mL vial equipped
2. 2
   workup.STIRRINGThe reaction was stirred at RT overnight
3. 3
   세척The organic phase was washed with saturated NaHCO3, and brine
4. 4
   건조dried over Na2SO4
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo
7. 7
   기타The crude was purified by silica gel chromatography (4%-6% MeOH—CH2Cl2)

실험 절차

To a 20 mL vial equipped with stirring was added 3-(3,4-dichloro-benzenesulfonylamino)-3-phenyl-propionic acid (128 mg, 0.34 mmol), 6-(2-dimethylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-1-ylamine (40 mg, 0.17 mmol), EDC (Aldrich, 49 mg, 0.26 mmol), HOBt (Aldrich, 23 mg, 0.17 mmol), and CH2Cl2 (1 mL). The reaction was stirred at RT overnight and diluted with CH2Cl2 (50 mL). The organic phase was washed with saturated NaHCO3, and brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude was purified by silica gel chromatography (4%-6% MeOH—CH2Cl2) to afford the title compound as a white solid. MS (ESI): 590 (M+H)+.

출처