반응 #60386

반응 방정식

diethyl azodicarboxylate

6-hydroxy-1-tetralone

N,N-dimethylethanolamine

triphenylphosphine

→

product

6-(2-dimethylamino-ethoxy)-3,4-dihydro-2H-naphthalen-1-one

용매

THF

반응 조건

후처리

1. 1
   기타The solvent was evaporated in vacuo
2. 2
   기타The residue was purified by silica gel chromatography (3%-5% MeOH—CH2Cl2)

실험 절차

To a mixture of 6-hydroxy-1-tetralone (Aldrich, 1.0 g, 6.17 mmol, 1.0 eq), N,N-dimethylethanolamine (Aldrich, 0.93 mL, 9.26 mmol, 1.5 eq), and triphenylphosphine (Aldrich, 2.43 g, 9.26 mmol, 1.5 eq) in THF (10 mL) was added diethyl azodicarboxylate (Aldrich, 1.94 mL, 12.34 mmol, 2.0 eq) at 0° C. The reaction mixture was gradually warmed to RT and continued to stir overnight. The solvent was evaporated in vacuo. The residue was purified by silica gel chromatography (3%-5% MeOH—CH2Cl2) to provide the product as orange oil. MS (ESI): 234 (M+H)+.

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