반응 #60378

반응 방정식

3-(5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylonitrile

3-(3,4-dichlorobenzene-sulfonylamino)-3-(4-fluoro-phenyl)-propionic acid

HATU

EDC

DIEA

→

final compound

N-[6-(2-Cyano-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-3-(3,4-dichloro-benzenesulfonylamino)-3-(4-fluoro-phenyl)-propionamide

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타Solvent was evaporated in vacuo
2. 2
   기타The residue was purified by chromatography on silica gel
3. 3
   세척Elution with Hex

실험 절차

To a solution of 3-(5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylonitrile (100 mg, 0.504 mmol) in CH2Cl2 (10 mL) was added 3-(3,4-dichlorobenzene-sulfonylamino)-3-(4-fluoro-phenyl)-propionic acid (210 mg, 0.554 mmol), HATU (96 mg, 0.252 mmol), EDC (106 mg, 0.55 mmol), and DIEA (0.17 mL, 1.008 mmol). The resulting mixture was stirred at RT for 18 h. Solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel. Elution with Hex:Acetone mixture (75:25) gave final compound. MS m/z: 573.12 (M+H). Calc'd. for C28H24Cl2FN3O3S-572.48.

출처