반응 #60342

반응 방정식

tert-Butyl-chloro-dimethyl-silane

4-chromanol

N-methylmorpholine

imidazole

→

title compound

tert-butyl-(chroman-4-yloxy)-dimethyl-silane

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   세척washed with dilute HCl and H2O
2. 2
   건조dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated in vacuo

실험 절차

tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.

출처