반응 #6026

반응 방정식

product

methyl 4-hydroxy-3,5-di(2-propen-1-yl)benzoate

tert-butyldimethylsilyl chloride

triethylamine

→

title compound

수율 97.2%

methyl 4-tert-butyldimethylsilyloxy-3,5-di(2-propen-1-yl)benzoate

수율 97.2%

용매

dichloromethane

반응 조건

후처리

1. 1
   농축The mixture was concentrated
2. 2
   기타flash chromatographed with 5%

실험 절차

The product of Step B (3.1 g, 13.36 mmol) was treated with tert-butyldimethylsilyl chloride (2.22 g, 1.1 equiv), triethylamine (3 mL) and DMAP (0.1 equiv) in dichloromethane overnight. The mixture was concentrated and flash chromatographed with 5% and then 10% ethyl acetate in hexane to furnish 4.5 g (97%) of the title compound.

출처