반응 #60253

반응 방정식

(2-bromo-ethoxy)-carbamic acid tert-butyl ester

morpholine

→

desired product

수율 46.0%

(2-Morpholin-4-yl-ethoxy)-carbamic acid tert-butyl ester

수율 46.0%

용매

EtOAc

DMF

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   건조The organic layer is dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타purified by flash chromatography (2% MeOH in CH2Cl2)

실험 절차

To a solution of (2-bromo-ethoxy)-carbamic acid tert-butyl ester (252 mg, 1.05 mmol) in DMF (2 mL) at room temperature is added morpholine (0.14 mL, 1.6 mmol). The reaction mixture is stirred for 7 hours at 50° C. The reaction mixture is diluted with EtOAc, and washed with water. The organic layer is dried over MgSO4, filtered, concentrated, and purified by flash chromatography (2% MeOH in CH2Cl2) to give the desired product (118 mg, 46%): MS APCI (+) m/z 247 detected.

출처