반응 #60226

반응 방정식

2-(2,4-dichlorophenyl)-6-chloro-3-nitropyridine

(2-aminoethyl)(6-amino-5-nitro(2-pyridyl))amine

N,N-diisopropylethylamine

→

{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-nitro(2-pyridyl)]amine

용매

DMF

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONdiluted with water and ethyl acetate
3. 3
   추출The solution was extracted three times with ethyl acetate
4. 4
   건조dried over sodium sulfate
5. 5
   기타purified by column chromatography
6. 6
   세척eluting with 5-10% methanol/methylene chloride

실험 절차

1 mmol of 2-(2,4-dichlorophenyl)-6-chloro-3-nitropyridine was taken with 2 mmol of (2-aminoethyl)(6-amino-5-nitro(2-pyridyl))amine and 3 mmol of N,N-diisopropylethylamine in 2 ml of DMF at 80° C. for two hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate, dried over sodium sulfate, and purified by column chromatography eluting with 5-10% methanol/methylene chloride.

출처