반응 #6021

반응 방정식

product

Methyl 2-(4-methylphenoxy)-2-(2'-chlorophenyl)acetate

N-bromosuccinimide

AIBN

→

Methyl 2-(4-bromomethylphenoxy)-2-(2'-chlorophenyl)acetate

수율 73.0%

용매

CCl4

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   기타chromatographed on silica gel (125×20 mm)
3. 3
   세척eluting with 5% ethyl acetate in hexane
4. 4
   기타The product was isolated in a 73% yield (186 mg)

실험 절차

A solution of the product of Example 3, Step B (0.2 g, 0.69 mmol), N-bromosuccinimide (117 mg, 166 mmol) and a catalytic amount of AIBN in 2 ml CCl4 was refluxed for 30 minutes. The reaction mixture was concentrated in vacuo and chromatographed on silica gel (125×20 mm) eluting with 5% ethyl acetate in hexane. The product was isolated in a 73% yield (186 mg).

출처