반응 #601568

반응 방정식

2-hexanone

DMF-DMA

→

title compound

수율 19.3%

(1E)-1-(dimethylamino)hept-1-en-3-one

수율 19.3%

용매

DMF

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   농축concentrated
3. 3
   기타purified by flash column chromatography (PE/EtOAc=4:1-2:1)

실험 절차

A solution of 2-hexanone (2.0 g, 20 mmol) and DMF-DMA (2.4 g, 20 mmol) in DMF (10 mL) was stirred at 100° C. overnight. The reaction mixture was cooled, concentrated, and purified by flash column chromatography (PE/EtOAc=4:1-2:1) to give the title compound (0.6 g, 19%) as yellow oil.

출처