반응 #601250

반응 방정식

compound 59

(S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(pyrimidin-2-yl)naphthalen-2-yl)acetic acid

2-bromopyrimidine

→

title compound

(S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-6-(imidazo[1,2-a]pyrazin-8-yl)-3-methylnaphthalen-2-yl)acetic acid

반응 조건

실험 절차

(S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-6-(imidazo[1,2-a]pyrazin-8-yl)-3-methylnaphthalen-2-yl)acetic acid (61) was prepared in a similar fashion to compound 59 with the substitution of 8-chloroimidazo[1,2-a]pyrazine hydrobromide (See Guzi, T. J, Paruch, K., et. al. US 20070105864, p. 121) for 2-bromopyrimidine in step 2. The title compound (0.017 g) was isolated as an amorphous pale yellow powder. LCMS-ESI+ (m/z): [M+H]+ calcd for C29H27ClN3O3: 500.7; found: 500.0. 1H-NMR: 400 MHz, (CD3CN) δ: 9.00 (d, J=1.2 Hz, 1H); 8.39 (d, J=4.4 Hz, 1H); 8.20 (dd, J=8.8, 1.2 Hz, 1H); 8.11 (d, J=4.4 Hz, 1H); 8.06 (d, J=1.2 Hz, 1H); 7.99 (s, 1H); 7.62-7.56 (m, 3H); 7.38 (d, J=8.8 Hz, 1H); 7.36 (br d, J=8.8 Hz, 1H); 5.25 (s, 1H); 2.58 (s, 3H); 0.99 (s, 9H).

출처