반응 #600707

반응 방정식

5-trifluoromethyl-quinolin-8-ylamine

5-(trifluoromethyl)quinolin-8-amine

4-chloro-2-nitrobenzene-1-sulfonyl chloride

4-chloro-2-nitrobenzenesulfonylchloride

Intermediate 454

4-chloro-2-nitrobenzenesulfonylchloride

pyridine

Intermediate 45

5-(trifluoromethyl)quinolin-8-amine

→

title compound

수율 46.8%

4-Chloro-2-nitro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide

수율 46.8%

용매

DCM

반응 조건

실험 절차

In a similar fashion using route 14 general procedure 27, 5-trifluoromethyl-quinolin-8-ylamine (Intermediate 45) (390 mg, 1.83 mmol), 4-chloro-2-nitrobenzene-1-sulfonyl chloride (Intermediate 454) (565 mg, 2.22 mmol), DMAP(cat) and pyridine (0.3 ml, 5.55 mmol) in DCM (7 ml) gave the title compound (370 mg, 46%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.

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