반응 #600464

반응 방정식

4-(3-(1H-imidazol-1-yl)benzylamino)-6-chloronicotinamide

4-amino-N,N-dimethylbenzamide

Cs2CO3

BINAP

→

titled compound

수율 9.0%

4-(3-(1H-imidazol-1-yl)benzylamino)-6-(4-(dimethylcarbamoyl)phenylamino)nicotinamide

수율 9.0%

용매

dioxane

반응 조건

후처리

1. 1
   기타was degassed with Ar
2. 2
   농축The mixture was concentrated in vacuo
3. 3
   기타the residue was purified by HPLC

실험 절차

A mixture of 4-(3-(1H-imidazol-1-yl)benzylamino)-6-chloronicotinamide (56 mg, 0.170 mmol), 4-amino-N,N-dimethylbenzamide (42 mg, 0.256 mmol), Cs2CO3 (110 mg, 0.337 mmol), BINAP (25 mg, 0.040 mmol) and Pd(OAc)2 (15 mg, 0.066 mmol) in dioxane (2 mL) was degassed with Ar, then was stirred at 120 C for 3 h. The mixture was concentrated in vacuo, the residue was purified by HPLC to give the titled compound (7 mg). MS 456.3 (M+H); UV 257.8 nm; t 0.344 min.

출처